Melanotan II, done right — or not at all.

Melanotan II is a synthetic analog of alpha-melanocyte-stimulating hormone, one of the body's own signaling peptides. It acts as an agonist at melanocortin receptors, and unlike more targeted molecules it engages several of them rather than one. Those receptors sit in different tissues and are involved in different processes, including pigmentation and central pathways related to sexual function. It is coming soon to Promise, where it will be prescription-only, after a licensed provider reviews your history.

A real prescription. Melanotan II is coming soon to Promise, and when visits open, a licensed provider will review your history before deciding whether to prescribe it; if it is prescribed, a licensed U.S. pharmacy will compound the medication for you. It will not be a product labeled for laboratory use.

No. A licensed provider reviews every Melanotan II request and prescribes only when it is appropriate for you. If it isn't, you'll be told plainly — that review is the point.

Directly. PT-141, also called bremelanotide, is a metabolite of Melanotan II — the body produces it as Melanotan II is broken down — and it acts on the same receptor family. The difference that matters is selectivity. PT-141 is the more selective and far better characterized of the two, with a real Western clinical record behind it. Melanotan II is the broader, less studied parent compound. PT-141 is prescribed here after a provider review and Melanotan II is coming soon; which one — if either — fits your history is your provider's decision.

No. Melanotan II is not FDA-approved. It is coming soon to Promise as a compounded medication, and compounded medications are not reviewed by the FDA for safety, effectiveness, or quality. It has never completed a U.S. approval process, and unregulated material sold outside a pharmacy channel has been the subject of health-authority warnings in several countries.

Yes. Melanotan II is coming soon to Promise — you can add your email on this page to hear when visits open. Once visits open, you complete the intake questionnaire built for Melanotan II, its own clinical form covering your health history, your skin history including any moles or other pigmented lesions, cardiovascular history, current medications, and what you are trying to address. A licensed provider reviews your answers and prescribes only when Melanotan II is appropriate for you; not everyone qualifies. If you are prescribed, a licensed U.S. compounding pharmacy prepares and dispenses your medication and ships it in temperature-safe packaging, with follow-up check-ins from your care team.

Because a molecule that activates several receptors at once has effects in several tissues at once, and a person cannot assess that for themselves. Melanocortin signaling reaches pigmented tissue, so any change in a mole or other pigmented lesion is something a clinician would want to examine rather than watch. Reported effects also include nausea and flushing, and there are cardiovascular questions worth a proper history. A licensed provider reviews every request and prescribes only when treatment is appropriate.

Melanotan II sold online without a prescription is usually labeled for laboratory use, with no provider, no pharmacy, and no one accountable if something goes wrong — and unregulated material has drawn health-authority warnings in several countries. Promise works the way medicine is supposed to: a licensed provider decides, a licensed U.S. pharmacy compounds your prescription, and a care team follows up.