Calming & stress relief is a category of one: a compounded peptide studied around slow-wave sleep architecture and stress-hormone signaling. The human evidence is limited, and a licensed provider reviews every request.
Calming & Stress Relief
Delta Sleep-Inducing Peptide, a nine-amino-acid peptide first isolated in the 1970s; research interest centers on slow-wave sleep architecture and the stress axis.
Requires an online medical evaluation. Prescribed only when a licensed provider determines it's appropriate.
Calming & Stress Relief
A synthetic tuftsin analog developed in Russia and studied around anxiolytic signaling, offered on Promise today only inside the Semax / Selank combination rather than on its own.
Requires an online medical evaluation. Prescribed only when a licensed provider determines it's appropriate.
From first intake to ongoing care — a clear path, guided by a clinician.
Share your health history, goals, and current medications in a few minutes.
Review your goals and options with a provider experienced in peptide therapy.
If appropriate, get a custom protocol with clear, step-by-step instructions.
Regular check-ins and adjustments keep you supported and on track.
This category holds a single compound, and the most useful thing we can do with the space is be straight about it.
DSIP — delta sleep-inducing peptide — is a nonapeptide first described in the late 1970s, isolated from the cerebral blood of rabbits that were in slow-wave sleep at the time. It was named for the state it was found in, not for a demonstrated effect. Half a century later that name still does more work in marketing copy than the evidence supports.
DSIP is not a sleep aid, and nothing on this page should be read as a claim that it induces sleep, improves sleep, or treats insomnia or anxiety. It is not approved for those uses, and the studies do not support that framing.
The human research is genuinely limited and inconsistent. It consists largely of small studies, many decades old, using varied dosing, varied routes, and varied outcome measures; results have pointed in different directions and have not been consolidated by large modern trials. Where a compound has been studied for fifty years without a clear answer, the honest summary is that there is no clear answer.
Two threads recur. The first is sleep architecture — the proportion and distribution of slow-wave sleep across the night, measured on EEG, as distinct from how long someone sleeps or how rested they report feeling.
The second is the hypothalamic-pituitary-adrenal axis, the stress-hormone system that governs cortisol and ACTH release. Research interest centers on whether DSIP participates in modulating that signaling. Interest is not evidence of benefit, and we are not going to present it as such.
DSIP has its own clinical questionnaire covering medical history, current medications, sleep and stress patterns, and what you have already tried. A licensed provider reviews it and prescribes only when it is appropriate for you.
With a thin evidence base, that review carries more weight than usual. Persistent sleeplessness, daytime exhaustion, or anxiety deserves a diagnostic look rather than a peptide: sleep apnea, thyroid conditions, medication effects, alcohol, pain, and mood disorders are common, treatable, and frequently missed. A provider may well decline and point you toward that evaluation instead, which is the correct outcome when it is the right one.
DSIP as offered here is a compounded medication and is not FDA-approved. Compounded medications are prepared for an individual patient by a state-licensed pharmacy under a prescription and are not reviewed by the FDA for safety, effectiveness, or quality. If prescribed, a licensed U.S. pharmacy compounds and ships it with dosing instructions, and follow-up check-ins keep the plan under review.
If your interest is closer to focus, mood, and cognition than to sleep and stress signaling, brain health and memory is the better starting point.
We do not claim that it does. Despite the name, the human evidence around DSIP is limited and inconsistent, and it is not a treatment for insomnia. Research has examined slow-wave sleep architecture and stress-hormone signaling; that is interest, not proof, and your provider will discuss what is and is not known.
Yes. DSIP is prescription-only. A licensed provider reviews every request and prescribes only when it is medically appropriate for you.
No. DSIP is a compounded medication and is not FDA-approved. Compounded medications are not reviewed by the FDA for safety, effectiveness, or quality; they are prepared for an individual patient by a state-licensed pharmacy under a prescription.
Two areas: slow-wave sleep architecture as measured on EEG, and modulation of the hypothalamic-pituitary-adrenal axis, the stress-hormone system involving cortisol and ACTH. The studies are small, largely decades old, and methodologically varied, and their findings have not been consistent.
That is a real possibility and part of what the review is for. Sleep apnea, thyroid conditions, medications, alcohol, pain, and mood disorders are common contributors and are treatable once identified.
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