Metabolic Support & Fat Loss · Rx only

Tirzepatide, prescribed — not just shipped.

Skip the gray-market guesswork. A licensed clinician reviews your health history, a licensed U.S. pharmacy compounds your prescription, and a care team stays with you after it ships.

$270 / mo$300 as a single month · $720 per quarter

Start visit

A licensed clinician reviews every request. If Tirzepatide fits your health history, they write your prescription and your pharmacy takes it from there.

Licensed U.S. providers Licensed U.S. pharmacy All 50 states + D.C.

Requires an online medical evaluation. Prescribed only when a licensed provider determines it's appropriate.

A licensed clinician in a consultation room
Tirzepatide vial beside a Promise product card
Tirzepatide · Rx only
1

Share your health history

Tirzepatide has its own online clinical questionnaire — your history, medications, and goals.

2

Your answers get a careful review

A clinician reads your history and takes the time to get it right before anything is prescribed.

3

Your pharmacy ships

Compounded for your prescription and shipped cold-chain, with care-team check-ins after.

The safe way to take Tirzepatide seriously

Tirzepatide is easy to find online and hard to trust there. Promise works the way medicine is supposed to work — a clinician decides, a licensed pharmacy fills, and someone stays accountable to you.

A real prescription

Prescribed for you specifically, after a real look at your health history — never pulled off a shelf.

A real pharmacy

Your prescription is compounded for you by a licensed U.S. pharmacy — not a mystery vial from an unregulated website.

Real oversight

Temperature-safe shipping, follow-up check-ins, and a care team that answers — before and after your medication arrives.

Product details
Form
Injectable vial (subcutaneous), compounded with vitamin B12
Supply
30-day supply
Pharmacy
Compounded by a licensed U.S. pharmacy
Availability
Ships to all 50 states + D.C.; not all treatments are available in every state

Two incretin receptors, one molecule

Tirzepatide is studied at GIP and GLP-1 receptors together — the pathways involved in satiety signaling, gastric emptying, and glucose-dependent insulin release.

Reviewed by a licensed provider

Every request is reviewed by a clinician, who prescribes only when treatment is appropriate.

Compounded, then shipped cold

Prepared by a licensed U.S. pharmacy, and delivered in temperature-safe packaging with follow-up check-ins.

In brief.

Tirzepatide is one molecule that acts on two incretin receptors at once — GIP and GLP-1 — compounded with vitamin B12 and prescribed for weight management alongside diet and exercise. The dual-pathway design is what distinguishes it from a single-receptor medication. A licensed provider reviews every request and prescribes only when treatment is appropriate for you.

What Tirzepatide is

Incretins are gut hormones released when you eat. Two of them do most of the signaling: GLP-1, which is involved in fullness and in how quickly the stomach empties, and GIP, the other major incretin, involved in insulin response and in how fat tissue handles incoming nutrients. Tirzepatide is a dual agonist — a single peptide built to bind both receptors, rather than the single-receptor design of Semaglutide.

Approved tirzepatide medicines exist, and the formulation Promise dispenses is not one of them: it is compounded with vitamin B12 by a licensed U.S. pharmacy and is not FDA-approved. The dual-receptor mechanism is well described in the literature; the preparation is a pharmacy's, and a provider's judgment is what connects it to you.

How it works in the body

At GLP-1 receptors, tirzepatide engages the same pathways a single agonist does: receptors in the hypothalamus involved in satiety, receptors that influence how fast a meal leaves the stomach, and receptors in the pancreas where insulin release is glucose-dependent rather than constant.

The GIP half is what makes it different. GIP receptors sit in the brain and in adipose tissue, and dual activation is studied for complementary effects on appetite signaling and on how the body handles nutrients — which is why tirzepatide is described as dual-pathway, not as stronger. A different mechanism is not the same thing as a better fit for you; which medication suits a given person is a clinical question.

The vitamin B12 in the compounded formulation is a common addition in compounded incretin preparations. It is not what drives the medication's activity, and your provider can explain how the pharmacy's preparation fits your protocol.

How it is prescribed

The Tirzepatide intake is its own clinical questionnaire — weight history, medical history, the personal and family history that matters for this class of medication, everything you currently take, and what you want treatment to address. It takes a while to complete, and that is the point.

A licensed provider reviews what you submit and prescribes only when treatment is appropriate for you. Certain histories rule this class out, and requests are declined; a decline is the review doing its job.

What treatment looks like

If you are prescribed, a licensed U.S. pharmacy compounds and dispenses your medication and ships it in temperature-safe packaging. Your provider sets the protocol, including how treatment begins and how it changes over time — Promise does not publish dosing, because it is not the same for everyone. Follow-up check-ins are part of the plan.

None of it replaces the fundamentals. Protein, resistance training, sleep, and eating patterns are what the medication is meant to work alongside, and providers keep raising them for that reason. If you are still deciding between the two incretin options in the metabolic support and fat loss category, that comparison is a conversation with your provider rather than a choice made from a product page.

Common questions

What is Tirzepatide?

Tirzepatide is a dual agonist: a single peptide that binds both the GIP and the GLP-1 receptor, the two incretin pathways involved in fullness, in how quickly the stomach empties, and in glucose-dependent insulin release. It is prescribed for weight management alongside diet and exercise. Promise dispenses it as a compounded formulation with vitamin B12, available only after a licensed provider reviews your health history.

Do I need a prescription for Tirzepatide?

Yes. Tirzepatide is prescription-only. You complete the intake form written for this product, a licensed provider reviews your health history and medications, and it is prescribed only when the provider determines it is appropriate for you.

Is Tirzepatide FDA-approved?

No — not the version Promise dispenses. Tirzepatide exists in FDA-approved products, but not the compounded formulation offered here, which is prepared with vitamin B12 by a licensed U.S. pharmacy and is not FDA-approved. Compounded medications are not reviewed by the FDA for safety, effectiveness, or quality, which is part of why a licensed provider reviews your health history and prescribes only when treatment is appropriate for you.

How does the online visit work?

You complete the Tirzepatide intake form online: weight and medical history, the personal and family history relevant to this class of medication, current medications, and your goals. A licensed provider reviews it and either prescribes, asks for more information, or declines if treatment is not appropriate for you. If it is prescribed, a licensed U.S. pharmacy compounds and ships your medication, and follow-up check-ins are part of the plan.

How is Tirzepatide different from Semaglutide?

Semaglutide acts at the GLP-1 receptor alone, while tirzepatide acts at the GLP-1 and GIP receptors together — two incretin pathways instead of one. That dual design is studied for complementary effects on appetite signaling and on how the body handles nutrients; it is a different mechanism, which is not the same as a better fit for any particular person. Both are compounded with vitamin B12 at Promise, and a licensed provider decides which, if either, is appropriate for you.

Related treatments

Other Metabolic Support & Fat Loss options a provider may consider.

Weight Semaglutide vial beside a Promise product card

Semaglutide

Metabolic Support & Fat Loss

GLP-1 support for appetite and weight goals.

About Semaglutide →

$220.50 / moStart visit

Requires an online medical evaluation. Prescribed only when a licensed provider determines it's appropriate.

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