GLP-1 medications
GLP-1 is a hormone your gut releases after you eat — it tells your brain you're full and helps your body manage blood sugar. GLP-1 medications (semaglutide, tirzepatide, and newer molecules) copy that signal, which is why they're so widely studied for weight management and metabolic health.
The articles below explain how these medications work, what the research actually shows, and what side effects and dosing schedules look like in practice. Promise offers compounded GLP-1 medications by prescription only: a licensed provider reviews every request, and not everyone qualifies.
136 articles on this topic
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Semaglutide Sulfur Burps: Why They Happen
Sulfur-smelling burps are a real but poorly measured digestive complaint with semaglutide. Trials counted belching, not its smell, and the likely explanation combines slower digestion with hydrogen-sulfide gas.
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Tirzepatide for PCOS: What the Evidence Shows
Early studies connect tirzepatide with weight and metabolic changes in people with PCOS, but the direct evidence is still small. Pregnancy plans and the reason for prescribing matter as much as the diagnosis.
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Tirzepatide Plateau: Why Weight Loss Slows
A tirzepatide plateau is usually the point where a smaller body and stronger biological pressure to maintain weight balance the medication's effects. A brief stall is not the same thing, and a prescriber should review the pattern before changing treatment.
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Is Semaglutide FDA Approved? Not When Compounded
Promise dispenses semaglutide as a compounded medication, which is different from an FDA-approved product: the formulation offered here is not FDA-approved. Ozempic, Rybelsus and Wegovy have approvals for specific uses.
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Semaglutide and Pregnancy: What the Evidence Says
Semaglutide is not recommended for routine weight management during pregnancy. The label calls for a two-month gap before planned conception, while early human exposure data remain limited rather than conclusive.
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Tirzepatide and Birth Control: The 4-Week Rule
Tirzepatide may reduce the absorption of birth control taken by mouth. The current U.S. labels advise non-oral contraception or an added barrier method for four weeks after starting and after every dose increase.
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Tirzepatide Benefits: What the Trials Show
Tirzepatide benefits are best established for weight reduction and blood-sugar control, with a branded indication for moderate-to-severe sleep apnea in adults with obesity. Heart failure, liver, blood-pressure and lipid findings are promising but narrower.
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Tirzepatide Constipation: How Long It Lasts
Tirzepatide constipation is common, especially in the first weeks and after dose increases. It often eases as treatment stabilizes, while severe or persistent symptoms need a clinician’s attention.
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Is Tirzepatide FDA Approved? Not When Compounded
Tirzepatide has branded approvals under Mounjaro and Zepbound. A compounded preparation is different from an FDA-approved product: the formulation offered here is not FDA-approved.
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Liraglutide vs Semaglutide: A Clear Comparison
Both are GLP-1 medicines, but liraglutide is usually injected daily and semaglutide weekly. Head-to-head trials show why the treatment goal and dose matter as much as the molecule.
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Semaglutide Constipation: What Helps
Semaglutide constipation is common during initiation and dose escalation. It usually eases, but it can last longer than other stomach side effects and deserves a clear plan with the prescriber.
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Tirzepatide Long-Term Side Effects: 3-Year Data
Three-year weight-management data and four-year cardiovascular data have not revealed a new late safety signal. They also do not tell us what decades of exposure will look like.
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What Happens When You Stop Taking Tirzepatide?
Appetite suppression fades as tirzepatide clears, and weight regain is common but neither immediate nor inevitable. SURMOUNT-4 shows the difference between stopping and continuing over one year.
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Peptides for Insulin Resistance: Evidence
The evidence runs from large clinical trials for semaglutide and tirzepatide to animal and observational research for MOTS-c. Those are not interchangeable levels of certainty.
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Does Semaglutide Cause Muscle Loss?
Semaglutide-related weight loss can include a drop in lean mass, but DXA lean mass is not the same as skeletal muscle. STEP 1 found fat fell faster than lean tissue, improving lean mass as a share of body weight.
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Tirzepatide for Type 2 Diabetes: Trial Results
Across the SURPASS trials, adults assigned to tirzepatide had average HbA1c reductions of roughly 1.9 to 2.4 percentage points over 40 to 52 weeks. The right comparison depends on a person's existing diabetes treatment and clinical risks.
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Can You Use HSA for GLP-1? Eligibility Rules
A prescribed GLP-1 may be HSA- or FSA-eligible when it treats a physician-diagnosed condition. The diagnosis, documentation and administrator's rules determine whether a claim is accepted.
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GLP-1 Drops: What the Absorption Evidence Shows
GLP-1 drops promise a needle-free shortcut, but the delivery system is the whole question. No published human clinical evidence yet shows that sublingual semaglutide drops achieve meaningful absorption or weight-loss efficacy.
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How Long Does GLP-1 Nausea Last?
A semaglutide nausea episode lasted a median of 8 days in pooled weight-management trials. Symptoms usually cluster around starting treatment and dose increases, then ease as titration settles.
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Does Semaglutide Make You Tired? What Trials Show
Yes, fatigue can happen, though it was reported by a minority of people in STEP trials. The timing and accompanying symptoms help distinguish low intake or dehydration from hypoglycemia or another cause.
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