A synthetic ACTH-fragment peptide studied around BDNF expression and neuromodulatory signaling. Available as a compounded nasal spray after a licensed provider review.
Coming soon
Promise is moving to a new prescriber network. Visits are paused while we make the switch — leave your email on any treatment page and we'll tell you when they reopen. A licensed provider will still review every request, and not everyone qualifies.
You are on the list. We will email you if Semax becomes available — and nothing else. Joining is not a medical request, and no prescription has been issued.
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Every treatment gets its own online clinical questionnaire — your history, medications, and goals.
A real person goes through your history and takes the time to get it right before anything is decided.
If a treatment isn't right for your history, you'll hear that plainly. That review is the whole point.
Made for your prescription by a licensed U.S. pharmacy and shipped in temperature-safe packaging.
Your care team checks in after it arrives. Adjust with your provider, or cancel at any time.
Semax is offered as a nasal spray. Your provider decides whether it's appropriate — including whether a different treatment would serve you better.
20 mg / 13 mcg per spray bottle
Semax is easy to find online and hard to trust there. Promise works the way medicine is supposed to work — a clinician decides, a licensed pharmacy fills, and someone stays accountable to you.
Prescribed for you specifically, after a real look at your health history — never pulled off a shelf.
Your prescription is compounded for you by a licensed U.S. pharmacy — not a mystery vial from an unregulated website.
Temperature-safe shipping, follow-up check-ins, and a care team that answers — before and after your medication arrives.
Semax is built from a short stretch of adrenocorticotropic hormone with a stabilizing tail added. The fragment it derives from carries none of the parent hormone's cortisol-releasing activity.
Research interest centers on brain-derived neurotrophic factor expression and on neuromodulatory pathways. That is a mechanism under study, not a described outcome in a person.
Semax is available as a nasal spray. A licensed provider reads your history, decides whether it fits, and may decline.
Semax is available through Promise as a compounded nasal spray. The standalone contains one peptide; Semax / Selank combines both peptides in one nasal preparation. A licensed provider reviews every request and prescribes only when Semax is appropriate.
Semax is a synthetic peptide built from a short stretch of adrenocorticotropic hormone, with a small proline-glycine-proline tail added to the end of the chain. That tail is the practical part of the design — it slows enzymatic breakdown enough for the molecule to be studied, and it is the same trick used to stabilize several peptides of this generation.
The fragment Semax derives from is not the part of ACTH that drives cortisol release. This matters, and it is often garbled in secondhand accounts: Semax is derived from a hormone but does not act as one. It belongs in our brain health and memory category because of where the research points, not because of anything hormonal.
Most of the mechanistic work on Semax concerns brain-derived neurotrophic factor — a protein involved in the survival, growth and maintenance of neurons — and related neuromodulatory signaling. Animal and laboratory studies have looked at how the peptide influences BDNF expression, and that is the finding usually cited.
A pathway is not a result. Saying a compound is studied around BDNF expression describes what researchers measured in a model; it says nothing about how any particular person will feel, think or perform. We are not going to bridge that gap with adjectives, and any page that does should be read with suspicion.
So this page makes no claim about memory, concentration or mental performance. What it can say honestly is that the mechanism is interesting enough to have kept researchers on it for decades.
Semax was developed at a Russian research institute and the bulk of its clinical literature was produced and published in Russia, in Russian. It is registered there as a medication and has been used clinically for years in that context.
Those studies exist, and some are human trials. They are also, for the most part, small, difficult to appraise from outside, and rarely replicated under contemporary Western trial standards. That combination — a long clinical history in one country and a thin independently auditable record elsewhere — is exactly why a compound like this belongs behind a clinician rather than in front of a page anyone can act on.
Semax is available as a nasal spray. The bottle strength is a product fact, not a public dosing schedule, and the provider sets any protocol after reviewing your history.
The standalone and Semax / Selank are different compounded preparations. The blend is not automatically stronger or better; a provider considers why one compound or the pair is being requested and whether either makes sense.
One question a clinician asks is why you want Semax without Selank beside it. The pair brings two different research pathways together, while the standalone narrows the formulation deliberately. That reason is worth understanding before anything is prescribed.
A licensed provider would then review the rest of it: your medications, your neurological and psychiatric history, and what you are actually trying to address. They prescribe only when a treatment is appropriate, and declining is a normal and expected outcome. If Semax is prescribed, a licensed U.S. pharmacy compounds and dispenses the nasal spray, and follow-up check-ins keep the provider involved.
Semax is a synthetic peptide built from a short fragment of ACTH — adrenocorticotropic hormone — with a small tail added to the chain so that enzymes break it down more slowly. The fragment it derives from does not carry the parent hormone's cortisol-releasing activity. Research interest centers on brain-derived neurotrophic factor expression and on neuromodulatory signaling. It was developed in Russia and is available through Promise as a compounded nasal spray after provider review.
A real prescription. Semax on Promise is prescribed by a licensed provider after a review of your health history and compounded for you by a licensed U.S. pharmacy. It is not a product labeled for laboratory use.
No. A licensed provider reviews every Semax request and prescribes only when it is appropriate for you. If it isn't, you'll be told plainly — that review is the point.
Standalone Semax contains one peptide in a nasal spray. Semax / Selank combines both peptides in one nasal preparation. A provider considers the clinical reason for using one compound or the pair rather than treating the blend as a stronger version.
No. Semax is not FDA-approved. It is prepared as a compounded medication, and compounded medications are not reviewed by the FDA for safety, effectiveness, or quality. Semax has never been through a U.S. approval process; it is registered in Russia, where it was developed and where most of its clinical literature was published.
Yes. Everything Promise offers is prescription-only. You would complete an intake questionnaire written for the compound, and a licensed provider would review your health history, current medications, and neurological or psychiatric history before deciding. They prescribe only when treatment is appropriate for you.
Semax was developed in Russia, and much of its clinical literature was produced and published there. Some studies involved people, but many are small, difficult to appraise independently, and rarely replicated under contemporary Western trial standards.
Semax sold online without a prescription is usually labeled for laboratory use, with no provider, no pharmacy, and no one accountable if something goes wrong. Promise uses a licensed provider review, a patient-specific prescription when appropriate, and a licensed U.S. compounding pharmacy.
Other Brain Health & Memory options a provider may consider.
Brain Health & Memory
Two Russian-developed peptides prescribed together: Semax, an ACTH fragment studied around BDNF expression, and Selank, a tuftsin analog studied around anxiolytic signaling.
Requires an online medical evaluation. Prescribed only when a licensed provider determines it's appropriate.
The latest from the Promise team on Semax.
Semax has never had an FDA-approved U.S. product. A July 2026 advisory vote supported possible 503A listing, but it did not add Semax to the list or approve a drug.
There is no measured Semax half-life in humans. Rat studies show that intact Semax reaches the brain within minutes and breaks down quickly, but they do not supply a reliable human clock.
A Semax Selank nasal spray puts both peptides in one intranasal liquid, but there is no universal recipe. The route, concentration, pump, and prescription all matter—and Promise's current blend is listed as an injectable vial, not a nasal spray.
Type a treatment, a goal, or a question.