Brain Health & Memory · Coming soon

Semax, done right — or not at all.

A synthetic ACTH-fragment peptide studied around BDNF expression and neuromodulatory signaling. Coming soon to Promise as a compounded nasal spray.

Coming soon

You are on the list. We will email you when Semax becomes available — and nothing else. Joining is not a medical request, and no prescription has been issued.

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Semax is coming soon to Promise. Add your email and we'll let you know when visits open.

We store your address and which treatment you asked about, and use it only to tell you if Semax becomes available. Joining is not a medical request and no prescription is issued from this form.

A licensed provider reviews every request; not everyone qualifies.

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Call (602) 737-2202

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A licensed clinician in a consultation room
Semax vial and spec card
Semax · Coming soon

How it works once Semax is available

  1. 1

    Share your health history

    Every treatment gets its own online clinical questionnaire — your history, medications, and goals.

  2. 2

    A licensed provider reads it

    A real person goes through your history and takes the time to get it right before anything is decided.

  3. 3

    They prescribe — or they don't

    If a treatment isn't right for your history, you'll hear that plainly. That review is the whole point.

  4. 4

    Your pharmacy compounds it

    Made for your prescription by a licensed U.S. pharmacy and shipped in temperature-safe packaging.

  5. 5

    You choose whether to continue

    Your care team checks in after it arrives. Adjust with your provider, or cancel at any time.

How Semax will be offered

Semax will be offered as a nasal spray. Your provider decides whether it's appropriate — including whether a different treatment would serve you better.

  • Nasal spray

    20 mg per bottle (13 mcg per spray)

The safe way to take Semax seriously

Semax is easy to find online and hard to trust there. Promise works the way medicine is supposed to work — a clinician decides, a licensed pharmacy fills, and someone stays accountable to you.

A real prescription

Prescribed for you specifically, after a real look at your health history — never pulled off a shelf.

A real pharmacy

Your prescription is compounded for you by a licensed U.S. pharmacy — not a mystery vial from an unregulated website.

Real oversight

Temperature-safe shipping, follow-up check-ins, and a care team that answers — before and after your medication arrives.

Product details
Available as
Nasal spray
Supply
20 mg per bottle (13 mcg per spray)
Pharmacy
Compounded by a licensed U.S. pharmacy
Availability
Coming soon — add me to the list to be notified

A fragment of ACTH, not the hormone

Semax is built from a short stretch of adrenocorticotropic hormone with a stabilizing tail added. The fragment it derives from carries none of the parent hormone's cortisol-releasing activity.

Studied around BDNF signaling

Research interest centers on brain-derived neurotrophic factor expression and on neuromodulatory pathways. That is a mechanism under study, not a described outcome in a person.

Nasal, prescribed and reviewed

Semax is coming soon to Promise as a nasal spray. When visits open, a licensed provider will read your history, decide whether it fits, and may decline.

In brief.

Semax is coming soon to Promise as a compounded nasal spray — add me to the list. The standalone contains one peptide; Semax / Selank combines both peptides in one preparation and is listed separately. A licensed provider reviews every request and prescribes only when Semax is appropriate.

What Semax is

Semax is a synthetic peptide built from a short stretch of adrenocorticotropic hormone, with a small proline-glycine-proline tail added to the end of the chain. That tail is the practical part of the design — it slows enzymatic breakdown enough for the molecule to be studied, and it is the same trick used to stabilize several peptides of this generation.

The fragment Semax derives from is not the part of ACTH that drives cortisol release. This matters, and it is often garbled in secondhand accounts: Semax is derived from a hormone but does not act as one. It belongs in our brain health and memory category because of where the research points, not because of anything hormonal.

What "studied around BDNF" means, and what it does not

Most of the mechanistic work on Semax concerns brain-derived neurotrophic factor — a protein involved in the survival, growth and maintenance of neurons — and related neuromodulatory signaling. Animal and laboratory studies have looked at how the peptide influences BDNF expression, and that is the finding usually cited.

A pathway is not a result. Saying a compound is studied around BDNF expression describes what researchers measured in a model; it says nothing about how any particular person will feel, think or perform. We are not going to bridge that gap with adjectives, and any page that does should be read with suspicion.

So this page makes no claim about memory, concentration or mental performance. What it can say honestly is that the mechanism is interesting enough to have kept researchers on it for decades.

What the evidence base looks like

Semax was developed at a Russian research institute and the bulk of its clinical literature was produced and published in Russia, in Russian. It is registered there as a medication and has been used clinically for years in that context.

Those studies exist, and some are human trials. They are also, for the most part, small, difficult to appraise from outside, and rarely replicated under contemporary Western trial standards. That combination — a long clinical history in one country and a thin independently auditable record elsewhere — is exactly why a compound like this belongs behind a clinician rather than in front of a page anyone can act on.

The nasal formulation

Semax is coming soon as a nasal spray. The bottle strength is a product fact, not a public dosing schedule, and the provider sets any protocol after reviewing your history.

The standalone and Semax / Selank are different compounded preparations. The blend is not automatically stronger or better; a provider considers why one compound or the pair is being requested and whether either makes sense.

How a provider approaches it

One question a clinician asks is why you want Semax without Selank beside it. The pair brings two different research pathways together, while the standalone narrows the formulation deliberately. That reason is worth understanding before anything is prescribed.

A licensed provider would then review the rest of it: your medications, your neurological and psychiatric history, and what you are actually trying to address. They prescribe only when a treatment is appropriate, and declining is a normal and expected outcome. If Semax is prescribed, a licensed U.S. pharmacy compounds and dispenses the nasal spray, and follow-up check-ins keep the provider involved.

Common questions

What is Semax?

Semax is a synthetic peptide built from a short fragment of ACTH — adrenocorticotropic hormone — with a small tail added to the chain so that enzymes break it down more slowly. The fragment it derives from does not carry the parent hormone's cortisol-releasing activity. Research interest centers on brain-derived neurotrophic factor expression and on neuromodulatory signaling. It was developed in Russia; it is coming soon to Promise as a compounded nasal spray.

Is this real Semax, or a research chemical?

A real prescription. Semax is coming soon to Promise, and when visits open, a licensed provider will review your history before deciding whether to prescribe it; if it is prescribed, a licensed U.S. pharmacy will compound the medication for you. It will not be a product labeled for laboratory use.

Does starting a visit guarantee a prescription?

No. A licensed provider reviews every Semax request and prescribes only when it is appropriate for you. If it isn't, you'll be told plainly — that review is the point.

How is standalone Semax different from Semax / Selank?

Standalone Semax contains one peptide in a nasal spray. Semax / Selank combines both peptides in one injectable preparation. A provider considers the clinical reason for using one compound or the pair rather than treating the blend as a stronger version.

Is Semax FDA-approved?

No. Semax is not FDA-approved. It will be prepared as a compounded medication, and compounded medications are not reviewed by the FDA for safety, effectiveness, or quality. Semax has never been through a U.S. approval process; it is registered in Russia, where it was developed and where most of its clinical literature was published.

Do I need a prescription for Semax?

Yes. Everything Promise offers is prescription-only, and Semax is coming soon. Once visits open, you complete an intake questionnaire written for the compound, and a licensed provider reviews your health history, current medications, and neurological or psychiatric history before deciding. They prescribe only when treatment is appropriate for you.

What does the evidence for Semax show?

Semax was developed in Russia, and much of its clinical literature was produced and published there. Some studies involved people, but many are small, difficult to appraise independently, and rarely replicated under contemporary Western trial standards.

How is this different from Semax sold online?

Semax sold online without a prescription is usually labeled for laboratory use, with no provider, no pharmacy, and no one accountable if something goes wrong. Promise uses a licensed provider review, a patient-specific prescription when appropriate, and a licensed U.S. compounding pharmacy.

Related treatments

Other Brain Health & Memory options a provider may consider.

Focus Semax / Selank vial and spec card

Semax / Selank

Brain Health & Memory

Two Russian-developed peptides prescribed together: Semax, an ACTH fragment studied around BDNF expression, and Selank, a tuftsin analog studied around anxiolytic signaling.

About Semax / Selank →

From $199Start visit

Requires an online medical evaluation. Prescribed only when a licensed provider determines it's appropriate.

Explore Brain Health & Memory →

Read more about Semax

The latest from the Promise team on Semax.

  1. A woman sits on the front steps of a house peeling an orange

    Should I Take Semax Selank? What a Provider Weighs

    A provider starts with your symptoms and current treatment. Small studies of the separate peptides don't settle whether the pair fits you.

    November 9, 2026 · Elena Marsh, Health Writer
  2. A man stands beside a bicycle in a quiet lane holding an apple

    10 Questions to Ask Before Semax or Selank

    Semax and Selank are not FDA-approved, and neither peptide has a U.S. prescribing label. A medical review relies on small human studies, foreign product sheets, and your health history.

    October 29, 2026 · Nadia Okonjo, Health Writer
  3. A man sits on a small balcony beside a basket of apples

    Semax Dosage: What Russian Labels and Studies Say

    Russian labels and small studies report very different Semax amounts. A prescriber sets any actual dose, timing, and follow-up.

    October 26, 2026 · Nadia Okonjo, Health Writer
All 18 articles on Semax →