How do peptides work?
How do peptides work? These mechanism articles are the how behind the what. If you want to understand what a GLP-1 dual agonist actually does after injection, why a growth hormone peptide works with your pituitary instead of around it, or which receptor a molecule binds — this is that shelf.
Written to be understood like you're fifteen, sourced from the primary literature, and honest wherever the mechanism is still a hypothesis rather than settled science.
148 articles on this topic
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SS-31 Peptide: A Patient's Guide to Elamipretide
SS-31 and elamipretide are two names for the same four-amino-acid peptide, and its branded injectable form received accelerated approval from the FDA on September 19, 2025 for a single ultra-rare genetic disease.
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What Does Tesamorelin Do?
In 26-week Phase 3 trials, daily tesamorelin reduced visceral abdominal fat by 10.9–15.4% in adults with HIV-associated lipodystrophy while placebo groups gained fat.
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CJC-1295 and Ipamorelin: Why They're Paired
One prescription, two receptors: CJC-1295 signals through the GHRH receptor while ipamorelin mimics ghrelin at GHSR-1a — two separate inputs to the same growth-hormone axis.
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How Does PT-141 Work? Brain, Not Blood Vessels
PT-141 initiates the arousal signal at melanocortin receptors in the hypothalamus rather than in blood vessels — a mechanism tested in 1,267 premenopausal women across two Phase 3 trials.
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Thymosin Alpha 1 Peptide: The Trial Record
Thymalfasin — the drug form of the thymosin alpha 1 peptide — is approved in over 30 countries, and the largest trial ever run on it, in 1,106 sepsis patients, returned a 28-day mortality hazard ratio of 0.97.
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MOTS-c Peptide Benefits: Rodent Depth, Human Hints
MOTS-c is a peptide your mitochondria encode themselves — and it is studied for how cells handle fuel. The rodent evidence runs deep; the human evidence is just beginning.
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The DSIP Peptide: A 1970s Sleep Mystery
The DSIP peptide was isolated from the blood of sleeping rabbits in 1970s Switzerland, yet no one has ever found its receptor — or the gene that would prove mammals make it.
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What Does Kisspeptin Do? The Signal Above GnRH
Kisspeptin sits one rung above GnRH in the reproductive axis, and the ~4-minute half-life routinely quoted for kisspeptin-10 — the form Promise dispenses — has been measured in people: 3.8 minutes in men, 4.1 in women.
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